In response to the mandate of the Special Session of the Forum of Ministers of Environment of Latin America and the Caribbean (Rio de Janeiro, 2024), this Regional Cooperation Programme aims to urgently and significantly reduce methane emissions from the waste sector and advance the progressive closure of dumpsites in the region. This is a regional challenge that requires concerted action: currently, 45% of municipal waste is not adequately managed, and more than 10,000 active dumpsites release uncontrolled methane emissions, posing risks to human health and the environment. Although organic waste accounts for 50% of total waste, less than 3% is recovered. The Programme sets forth a shared vision: By 2040, Latin American and Caribbean countries will have significantly reduced methane emissions from the waste sector, prevented the disposal of organic waste in landfills, and closed dumpsites. To achieve this, the Programme promotes integrated solutions across the entire waste management chain, with a menu of interventions from prevention (upstream), to deviation and valorization (midstream) and the improvement of final disposal infrastructure (downstream). Three priority areas of intervention have been defined: 1) Strengthening legal frameworks and enforcement; 2) Enhancing institutional and operational capacities, including MRV systems; 3) Mobilizing finance for waste methane mitigation and dumpsite closure. The Programme fosters cooperation activities focused on knowledge exchange, promotion of good practices, joint initiatives, and shared access to technical assistance and financial resources. It also includes an implementation strategy to support its adoption at national and subnational levels. This document has been prepared within the framework of the Forum of Ministers of Environment of Latin America and the Caribbean, through the Voluntary Coalition of Governments and Relevant Organizations for the Progressive Closure of Dumpsites in Latin America and the Caribbean. The development of the Programme was facilitated by the UNEP Latin America and the Caribbean Office, with the technical support of the Climate and Clean Air Coalition (CCAC).