Control of pollution from antibiotic manufacturing is a key part of safeguarding the longevity of antibiotics for all. Pollution contributes to antibiotic resistance and potentially undermines the effectiveness of medicines. High levels of antibiotics in water bodies downstream of manufacturing sites have been widely documented. Currently, antibiotic pollution from manufacturing is largely unregulated and quality assurance criteria typically do not address environmental emissions. This guidance has been called for by a myriad of international bodies, strategies and reports. Its purpose is to provide an independent scientific basis for inclusion of targets in binding instruments to prevent the emergence and spread of antibiotic resistance.The target audiences are: regulatory bodies; procurers of antibiotics; entities responsible for generic substitution schemes and reimbursement decisions; third-party audit and inspection bodies; industrial actors and their collective organizations and initiatives; investors; and waste and wastewater management services. This guidance also includes best practices for risk management, including internal and external audit and public transparency. Crucially, this guidance includes progressive implementation, and stepwise improvement when needed recognizing the need to protect and strengthen the global supply, and to ensure appropriate, affordable and equitable access to quality-assured antibiotics. Read the press release New global guidance aims to curb antibiotic pollution from manufacturing Also available Frequently asked questions Background document: Evidence synthesis for deriving PNECs for resistance selection
Builders face a decisive shift as sustainability in construction moves from the margins to the core of business strategy. Record renewable energy penetration in the UK and Uruguay has reduced the operational carbon footprint of energy-efficient buildings, accelerating the need for sustainable building design focused on embodied carbon and whole life carbon performance. With electrification of heat now delivering both cost and carbon savings, the spotlight is widening to encompass materials, logistics, circular economy practices and end-of-life reuse in construction. These transitions redefine sustainable building practices by linking grid decarbonisation with low carbon design and whole life carbon assessment.
Policy uncertainty remains a critical risk. The diversion of US offshore wind funding toward liquefied natural gas has disrupted the sustainable construction pipeline and increased the carbon footprint of construction through delayed infrastructure upgrades, as seen when offshore wind funding was redirected toward fossil fuels. Investors and developers now factor environmental sustainability in construction directly into life cycle cost models, integrating lifecycle assessment data and environmental product declarations (EPDs) to anticipate policy volatility and manage embodied carbon in materials more precisely.
Legal frameworks are evolving in parallel. Colombia’s exit from investor–state dispute settlement could expand national capacity to mandate stricter green building materials, low embodied carbon materials and sustainable material specification standards through public procurement and building codes. This shift strengthens the foundation for carbon neutral construction while compelling lenders to assess the environmental impact of construction alongside financial risk.
Across clean-grid markets, regulation is converging on net zero whole life carbon outcomes. Low carbon construction materials, modular methods and circular construction strategies are now decisive in tendering for BREEAM-rated and BREEAM V7 projects. Contractors committed to eco-design for buildings and sustainable architecture are embedding life cycle thinking in construction to deliver resource efficiency in construction and optimise building lifecycle performance. The race toward net zero carbon buildings underlines that energy policy is no longer peripheral—it is a primary design variable shaping environmental sustainability, sustainable urban development and the decarbonising of the built environment.
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